Does SCN5A mutation status predict outcomes in Brugada?

SCN5A truncating variants are associated with higher arrhythmic risk. However, most high-risk features are clinical: spontaneous Type 1 ECG, resuscitated VF, unexplained syncope, and male sex.

Does EPS predict outcomes in Brugada?

EPS role is controversial. Inducible VF at EPS confers higher risk in some studies but not others. Current guidelines (ESC 2022) do not routinely recommend EPS for risk stratification in asymptomatic Brugada.

When is ICD recommended in Brugada?

ICD is indicated for Brugada with resuscitated VF or spontaneous hemodynamically significant VT. ICD is recommended for Brugada with unexplained syncope (likely arrhythmic). Asymptomatic management remains debated.

Brugada SCN5A Risk Stratification

Stratify arrhythmic risk in Brugada syndrome based on SCN5A variant status, clinical presentation, electrophysiology study results, and spontaneous vs induced Type 1 ECG pattern.

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