What does the MAKE composite include?

MAKE = death OR dialysis dependence at 90 days OR >=25% sustained reduction in eGFR from baseline. MAKE-90 is the most commonly used primary endpoint in AKI trials.

Why is MAKE used instead of mortality alone?

Mortality alone misses important kidney-specific outcomes. MAKE captures clinically meaningful outcomes (dialysis dependence, CKD progression) even when mortality differences are not significant.

Is MAKE used in non-research settings?

MAKE is primarily a research endpoint but guides risk stratification. Patients who survive AKI with 25% eGFR loss should receive nephrology follow-up within 90 days per KDIGO.

MAKE Major Adverse Kidney Events Composite

Calculate major adverse kidney events (MAKE) composite: death, dialysis dependence, or 25% sustained eGFR reduction from baseline, used as primary endpoint in AKI clinical trials.

Use the full interactive calculator below, or

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