What is the current MPGN classification approach?

Current approach: classify by IF as C3-dominant (C3G) or immunoglobulin-dominant (IC-MPGN). IC-MPGN etiology: hepatitis C, cryoglobulinemia, SLE, monoclonal Ig. C3G: complement dysregulation.

What complement studies help distinguish MPGN types?

IC-MPGN: low C3 AND C4 (classical pathway activation). C3G: low C3, normal C4 (alternative pathway). Normal complement does not exclude either.

How does treatment differ between MPGN patterns?

IC-MPGN: treat underlying cause (HCV = antivirals; cryoglobulinemia = rituximab; monoclonal Ig = hematology). C3G: mycophenolate, steroids, consider eculizumab. All benefit from RAAS blockade.

MPGN Pattern Type 1 vs 2 vs 3

Differentiate MPGN histological pattern (Type 1 immune complex, Type 2 C3G/DDD, Type 3 immune complex subepithelial) and map to underlying etiology for targeted treatment.

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MPGN Pattern Type 1 vs 2 vs 3

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Frequently Asked Questions

What is the current MPGN classification approach?

What complement studies help distinguish MPGN types?

How does treatment differ between MPGN patterns?