NOAC Renal Dose Adjustment Calculator

Determines renal dose adjustments for NOACs. Apixaban: reduce to 2.5 mg BID if ≥2 of: age ≥80, weight ≤60 kg, creatinine ≥1.5 mg/dL. Rivaroxaban: avoid if CrCl <15 mL/min (AF); use with caution CrCl 15–30. Dabigatran: avoid if CrCl <30; reduce to 75 mg BID if CrCl 15–30 (US label). Edoxaban: 30 mg daily if CrCl 15–50 mL/min.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How to Use

Enter the values for the scenario you are assessing. Determines renal dose adjustments for NOACs. Apixaban: reduce to 2.5 mg BID if ≥2 of: age ≥80, weight ≤60 kg, creatinine ≥1.5 mg/dL. Rivaroxaban: avoid if CrCl <15 mL/min (AF); use with caution CrCl 15–30. Dabigatran: avoid if CrCl <30; reduce to 75 mg BID if CrCl 15–30 (US label). Edoxaban: 30 mg daily if CrCl 15–50 mL/min. Use the noac renal dosing result to inform your calculation.

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Frequently Asked Questions