Why is there a separate Reynolds Risk Score for women?

Women were underrepresented in Framingham; the Reynolds score was validated specifically in women (WHS cohort) and adds hsCRP and parental MI, which are particularly predictive in women.

What hsCRP level raises risk in the Reynolds score?

An hsCRP ≥2 mg/L significantly increases risk reclassification in women who would otherwise be considered intermediate risk by standard Framingham calculation.

Reynolds Risk Score for Women

Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.

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⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to use this calculator

1
Enter patient clinical data
Enter the patient's age, weight, lab values, vitals, or clinical findings into the Reynolds Risk Score for Women input fields.
2
Select the clinical scoring system
Select or confirm the appropriate clinical scoring system or reference range for the patient population.
3
Calculate the clinical score
Press Calculate to compute the clinical score, risk estimate, or diagnostic result.
4
Interpret the result
Review the output against the provided reference ranges, risk categories, or guideline thresholds. Consult a qualified clinician before acting on results.

Formula

Result = f(patient inputs, clinical reference)

patient inputs: Age, weight, height, lab values, vitals, or clinical findings entered into the Reynolds Risk (Women).
clinical reference: Reference range, scoring system, or population standard the result is compared against.
Result: Computed clinical score, risk estimate, or diagnostic value.

Clinical results are decision-support only and must be interpreted by a qualified clinician.

Glossary and Definitions

Clinical score: A numeric value derived from patient inputs that estimates risk, severity, or diagnostic likelihood for a given condition.
Reference range: The set of values considered normal for a healthy population, used to interpret a calculated result.
Sensitivity: The probability that a positive result correctly identifies a patient with the condition.
Specificity: The probability that a negative result correctly identifies a patient without the condition.
Reynolds risk score: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
Women cardiovascular risk: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
HsCRP: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
Family history MI: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
Framingham: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
Primary prevention: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
10-year CV risk: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.
Coronary artery disease: A key concept referenced by the Reynolds Risk (Women): Estimates 10-year cardiovascular risk in women by adding high-sensitivity CRP (hsCRP) and family history of premature MI to traditional Framingham variables (age, systolic BP, total cholesterol, HDL-C, smoking). Reclassifies ~40–50% of intermediate-risk women compared to Framingham alone.

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