What are the Sepsis-3 definitions for sepsis and septic shock?

Sepsis: suspected/confirmed infection + SOFA >=2 (organ dysfunction). Septic shock: sepsis + vasopressor need to maintain MAP >=65 mmHg + lactate >2 mmol/L after adequate fluid resuscitation. Septic shock hospital mortality >40%. Sepsis-3 replaced SIRS-based definitions, removing systemic inflammatory response criteria.

Why was SIRS removed from the sepsis definition in Sepsis-3?

SIRS criteria (fever/hypothermia, tachycardia, tachypnea, leukocytosis/leukopenia) are too non-specific - present in exercise, trauma, pancreatitis, and many non-infectious conditions. Sepsis-3 focuses on organ dysfunction (SOFA) as the key feature distinguishing sepsis from uncomplicated infection, with better prognostic accuracy.

Sepsis-3 Criteria Application Calculator

Apply 2016 Sepsis-3 definitions: sepsis (life-threatening organ dysfunction from infection = SOFA >=2 increase), and septic shock (vasopressor need + lactate >2 mmol/L despite adequate fluids).

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Frequently Asked Questions

What are the Sepsis-3 definitions for sepsis and septic shock?

Why was SIRS removed from the sepsis definition in Sepsis-3?