Vasopressor Selection & Dosing for Septic Shock

Guides vasopressor selection and dosing in septic shock. First-line: norepinephrine 0.01–3 mcg/kg/min IV. Add vasopressin 0.03 units/min (fixed dose) to spare norepinephrine and reduce dose when NE >0.25 mcg/kg/min. Second-line for refractory shock: epinephrine. Phenylephrine preferred when tachyarrhythmia precludes other vasopressors. Dopamine is not recommended as first-line.