What is the evidence for vasopressin in septic shock?

VASST trial: vasopressin 0.03 U/min added to norepinephrine did not reduce 28-day mortality vs norepinephrine alone overall, but in less severe septic shock (NE <15 mcg/min) showed mortality benefit. Vasopressin spares catecholamine doses and is preferred as second-line vasopressor per SSC guidelines.

At what dose should vasopressin be titrated in septic shock?

Fixed dose: 0.03 to 0.04 U/min (not titrated, unlike catecholamines). Maximum dose 0.04 U/min for septic shock - higher doses associated with ischemic complications (mesenteric, digital ischemia, myocardial). Wean vasopressin last after catecholamines when weaning vasopressors (VASST protocol: keep vasopressin constant while titrating NE).

Vasopressin Dose Range by Indication Calculator

Calculate vasopressin dose ranges for septic shock (0.03 to 0.04 U/min), vasodilatory shock post-cardiac surgery, and bleeding varices (0.2 to 0.4 U/min), with titration and weaning guidance.

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Vasopressin Dose Range by Indication Calculator

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Frequently Asked Questions

What is the evidence for vasopressin in septic shock?

At what dose should vasopressin be titrated in septic shock?