What triggers stroke-like episodes in MELAS?

Stroke-like episodes are thought to result from mitochondrial dysfunction in neurons causing energy failure. Triggers include intercurrent illnesses, valproate (contraindicated), physiological stress, and possibly seizures themselves.

How is MELAS managed acutely and long-term?

Acute management includes IV arginine or citrulline to improve NO bioavailability and reduce stroke-like episode severity. Long-term treatment includes coenzyme Q10, riboflavin, carnitine, and B vitamins, though evidence for these is limited.

MELAS Syndrome Severity Score

Assess disease severity in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) across neurological, systemic, and biochemical domains.

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Frequently Asked Questions

What triggers stroke-like episodes in MELAS?

How is MELAS managed acutely and long-term?