What antibody is most specific for SLE?

Anti-Sm (anti-Smith) is the most specific (>98%) for SLE, present in only 25-30% of SLE patients. Anti-dsDNA is 97% specific but also 70% sensitive during active disease. Both are included in ACR/EULAR 2019 SLE criteria.

What antibody is associated with diffuse SSc and poor prognosis?

Anti-RNA polymerase III (anti-RNAP3): diffuse cutaneous SSc, higher risk of scleroderma renal crisis. Anti-topoisomerase I (Scl-70): diffuse SSc with high ILD risk. Anti-centromere: limited SSc/CREST with low ILD but higher PAH risk.

What is the clinical significance of anti-Ro/SSA?

Anti-Ro/SSA: primary Sjögren's (~70%), SLE subacute cutaneous LE, neonatal lupus/congenital heart block. Anti-La/SSB accompanies anti-Ro in ~40-50% of pSS. Isolated anti-La/SSB without anti-Ro is unusual.

Connective Tissue Disease Autoantibody Interpretation Guide

Interpret autoantibody profile to distinguish connective tissue diseases. Maps anti-dsDNA, anti-Sm, anti-Ro/La, anti-RNP, anti-Scl-70, anti-centromere, anti-Jo-1, and ANCA patterns to likely CTD diagnoses with sensitivity/specificity data.

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Frequently Asked Questions

What antibody is most specific for SLE?

What antibody is associated with diffuse SSc and poor prognosis?

What is the clinical significance of anti-Ro/SSA?