What are high-risk factors for preeclampsia per USPSTF/ACOG?

Any one high-risk factor: prior preeclampsia, multifetal gestation, renal disease, autoimmune conditions (SLE, APLS), type 1 or 2 diabetes, chronic hypertension. OR 2+ moderate risk factors: nulliparity, obesity, family history PE, Black race, low SES, age 35+, prior adverse pregnancy outcome.

When should low-dose aspirin start for PE prevention?

Low-dose aspirin (81-150 mg daily) started at 12-16 weeks (before 16 is optimal). USPSTF recommends aspirin for all women at high risk for PE. ASPRE protocol uses 150 mg nightly; most US guidelines use 81 mg daily.

Does chronic hypertension significantly increase PE risk?

Chronic hypertension confers 15-25% risk of superimposed preeclampsia (vs 3-5% baseline). Poorly controlled hypertension carries higher risk. ACE inhibitors/ARBs must be discontinued preconception or before 12 weeks.

Preconception Preeclampsia Risk Assessment Tool

Assess preeclampsia risk before pregnancy using clinical risk factors. High-risk factors (prior PE, antiphospholipid syndrome, chronic hypertension, CKD, diabetes, multiple gestation) predict risk above 8% and justify aspirin prophylaxis planning.

Use the full interactive calculator below, or

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Frequently Asked Questions

What are high-risk factors for preeclampsia per USPSTF/ACOG?

When should low-dose aspirin start for PE prevention?

Does chronic hypertension significantly increase PE risk?