What are the RIFLE criteria thresholds for each stage?

RIFLE stages: Risk (R) — creatinine ×1.5 or GFR decrease >25%, or urine output 6 hours. Injury (I) — creatinine ×2 or GFR decrease >50%, or UO 12 hours. Failure (F) — creatinine ×3 or GFR decrease >75%, or creatinine ≥4 mg/dL with acute rise ≥0.5, or UO 24 hours or anuria for >12 hours. Loss (L) — complete loss of kidney function >4 weeks. End-stage (E) — complete loss >3 months.

How does RIFLE compare to KDIGO AKI staging?

KDIGO staging (2012) largely superseded RIFLE in clinical practice by adding absolute creatinine rise ≥0.3 mg/dL within 48 hours as a Stage 1 criterion (capturing early AKI RIFLE misses), and combining AKIN and RIFLE frameworks into unified stages (1/2/3 rather than R/I/F). KDIGO Stage 3 encompasses RIFLE Failure and adds initiation of RRT as a Stage 3 trigger. RIFLE remains widely cited in older literature and research, making familiarity with both systems valuable.

RIFLE Acute Kidney Injury Criteria

Stage acute kidney injury using the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage) based on serum creatinine rise, GFR reduction, and urine output to guide nephrology consultation.

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Frequently Asked Questions

What are the RIFLE criteria thresholds for each stage?

How does RIFLE compare to KDIGO AKI staging?