How is mRSS calculated in systemic sclerosis?

mRSS assesses skin thickness at 17 body sites scored 0-3 (0=normal, 1=mild, 2=moderate, 3=severe); maximum total 51; significant increase ≥3-5 points; dcSSc typically has mRSS >15; lcSSc often ≤10.

What mRSS change is clinically significant?

mRSS change ≥3-5 units on 0-51 scale is considered minimal clinically important difference; significant spontaneous fluctuation occurs in dcSSc; mRSS peak at 2-4 years after onset, then slow improvement in most dcSSc.

What ILD screening is recommended in SSc?

Baseline HRCT chest and PFT (FVC, DLCO) in all SSc; high-risk features: anti-Scl-70 antibody, dcSSc, low DLCO, desaturation on walk test; nintedanib approved for SSc-ILD; mycophenolate mofetil as anchor.

What PH screening protocol is recommended in SSc?

Annual echocardiogram and PFT; DETECT algorithm uses 6 variables (DLCO, forced vital capacity, N-terminal pro-BNP, urate, right axis deviation, telangiectasia) to guide right heart catheterization.

Which SSc autoantibodies predict different phenotypes?

Anti-centromere: lcSSc, PH risk, low ILD risk; Anti-Scl-70 (anti-topoisomerase I): dcSSc, high ILD risk; Anti-RNA polymerase III: dcSSc, renal crisis risk; Anti-Th/To: lcSSc, ILD+PH risk.

Systemic Sclerosis Skin Thickness (mRSS) and EUSTAR Severity Score

Calculates modified Rodnan Skin Score (mRSS) for systemic sclerosis, EUSTAR-derived early mortality risk, pulmonary hypertension screening parameters, and ILD progression risk stratification.

Use the full interactive calculator below, or

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Systemic Sclerosis Skin Thickness (mRSS) and EUSTAR Severity Score

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Frequently Asked Questions

How is mRSS calculated in systemic sclerosis?

What mRSS change is clinically significant?

What ILD screening is recommended in SSc?

What PH screening protocol is recommended in SSc?

Which SSc autoantibodies predict different phenotypes?