What SDI score predicts mortality?

SDI ≥3 is associated with significantly increased mortality risk in SLE. Even a score of 1 predicts future damage accrual. Lower cumulative SDI is a major treatment goal.

What organ systems does SDI cover?

12 systems: ocular, neuropsychiatric, renal, pulmonary, cardiovascular, peripheral vascular, GI, musculoskeletal, skin, endocrine, reproductive, and malignancy.

Does SDI increase or decrease over time?

SDI only increases—damage is irreversible by definition. Scoring items only if present ≥6 months and not due to active disease avoids confounding with SLEDAI-type activity scores.

SLICC/ACR Damage Index for Lupus

Calculate the SLICC/ACR Damage Index (SDI) for SLE, measuring cumulative irreversible organ damage in 12 systems. Damage items must be present ≥6 months and not attributable to active inflammation.

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