What is included in the SLICC damage index?

SDI covers 12 organ systems: ocular, neuropsychiatric, renal, pulmonary, cardiovascular, peripheral vascular, GI, musculoskeletal, skin, endocrine, gonadal, and malignancy; maximum score 47.

What SDI score is associated with significantly increased mortality?

SDI ≥2 doubles 5-year mortality risk compared to SDI 0; each 1-point increase in SDI increases mortality risk by ~33%; renal and neuropsychiatric damage are highest-impact domains.

How does glucocorticoid use contribute to SDI?

Avascular necrosis, osteoporotic fractures, diabetes, and cataracts from glucocorticoids contribute substantially to SDI; steroid-sparing approaches with hydroxychloroquine and immunosuppressants aim to reduce SDI accrual.

What SLEDAI score indicates high disease activity in SLE?

SLEDAI-2K score 0: no activity; 1-5: mild; 6-10: moderate; 11-19: high; ≥20: very high. Flares defined as ≥4 point increase. BILAG scores each organ domain separately.

What new therapies reduce SDI in SLE?

Belimumab reduces flare rate and SDI accrual vs standard of care; anifrolumab (type I IFN blocker) reduces disease activity; voclosporin + MMF shows improved complete renal remission in lupus nephritis.

SLE Damage Index (SDI/SLICC) Calculator

Calculates the SLICC/ACR Damage Index for systemic lupus erythematosus to assess irreversible organ damage across 12 domains, correlate with mortality risk, and guide treatment intensity decisions.

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Frequently Asked Questions

What is included in the SLICC damage index?

What SDI score is associated with significantly increased mortality?

How does glucocorticoid use contribute to SDI?

What SLEDAI score indicates high disease activity in SLE?

What new therapies reduce SDI in SLE?