What are ASDAS disease activity thresholds?

ASDAS-CRP: inactive disease 3.5; clinically important improvement (CII) defined as decrease ≥1.1; major improvement as decrease ≥2.0.

What is the ASDAS-CRP formula?

ASDAS-CRP = 0.12 × back pain + 0.06 × duration morning stiffness + 0.11 × patient global + 0.07 × peripheral pain/swelling + 0.58 × ln(CRP+1); CRP in mg/L.

What is ASDAS inactive disease vs DAS28 remission?

ASDAS inactive disease (<1.3) is comparable to DAS28 remission for SpA; achieving ASDAS ID is the treatment target in axial SpA treat-to-target strategies; ASDAS <2.1 is low disease activity (acceptable alternative target).

Which biologics are approved for ankylosing spondylitis?

TNF inhibitors: adalimumab, certolizumab, etanercept, golimumab, infliximab; IL-17A inhibitors: secukinumab, ixekizumab; IL-23 inhibitor: risankizumab; JAK inhibitors: upadacitinib, tofacitinib for AS.

Does CRP need to be elevated for ASDAS calculation?

CRP can be zero; ln(0+1) = 0 is used for undetectable CRP; low CRP with high patient-reported symptoms still yields a meaningful ASDAS score; ASDAS-CRP is preferred over ASDAS-ESR in clinical practice.

ASDAS-CRP (Ankylosing Spondylitis Disease Activity Score) Calculator

Calculates ASDAS-CRP for axial spondyloarthritis using back pain (Q2+Q3), peripheral joint pain, enthesitis, morning stiffness, and CRP to assess disease activity state and treatment response.

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