What temperature target is recommended after cardiac arrest?

TTM2 trial (2021): preventing fever (36°C) was non-inferior to hypothermia (33°C) for neurological outcomes; current practice: prevent fever >37.7°C for 72h; active cooling to 33°C still reasonable in specific high-risk patients (e.g., prolonged downtime, non-shockable rhythm).

How long should TTM be maintained?

TTM at target temperature for 24 hours followed by controlled rewarming at 0.25-0.5°C/hour to 36°C; maintain 36°C for another 24h (total 48h temperature control); avoid fever >37.7°C for at least 72h after ROSC.

What drugs interfere with neuroprognostication after cardiac arrest?

Sedatives (propofol, midazolam), opioids, neuromuscular blocking agents, hypothermia itself, and metabolic derangements all confound neurological examination; a minimum of 72h after ROSC (and warming) is required before reliable assessment.

What multimodal neuroprognostication is recommended post-arrest?

ILCOR guidelines: ≥72h after ROSC; poor outcome predictors: absent pupillary light reflex, absent corneal reflex, absent N20 SSEP, burst suppression on EEG, diffuse anoxic injury on CT/MRI, NSE >60 μg/L at 48-72h.

What is the role of coronary angiography after OHCA?

TOMAHAWK trial (2021): immediate coronary angiography vs delayed/selective did not reduce mortality in comatose patients without ST elevation; STEMI with cardiac arrest still warrants immediate PCI; routine angiography without STEMI not recommended.

Post-Cardiac Arrest Targeted Temperature Management (TTM) Protocol

Guides targeted temperature management protocol after cardiac arrest with temperature target (33°C vs 36°C), cooling duration, and neuroprognostication timeline based on TTM1 and TTM2 trials.

Weight

Height

Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Guides targeted temperature management protocol after cardiac arrest with temperature target (33°C vs 36°C), cooling duration, and neuroprognostication timeline based on TTM1 and TTM2 trials

Each component has a specific meaning:

TTM1 — The ttm1 recorded for the patient or scenario being assessed.
TTM2 trials — The ttm2 trials recorded for the patient or scenario being assessed.

Note: Interpret the ttm post-arrest result against the clinical thresholds and context described above.

How to Use

Enter the TTM1, TTM2 trials for the patient or scenario you are assessing. Guides targeted temperature management protocol after cardiac arrest with temperature target (33°C vs 36°C), cooling duration, and neuroprognostication timeline based on TTM1 and TTM2 trials. Use the ttm post-arrest result to inform your clinical assessment.

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