What does each SOFA domain measure?

Respiratory: PaO2/FiO2 ratio (0-4); Coagulation: platelet count (0-4); Liver: bilirubin (0-4); Cardiovascular: vasopressor dose (0-4); CNS: GCS (0-4); Renal: creatinine/urine output (0-4); total maximum 24 points.

What SOFA score is used in Sepsis-3 definition?

Sepsis-3 defines sepsis as suspected infection plus acute SOFA increase ≥2 points above baseline, indicating life-threatening organ dysfunction; this replaced the SIRS-based definition from 1991 Sepsis-1.

What SOFA score indicates high mortality risk?

SOFA 0-6: ~10% mortality; 7-9: ~15-20%; 10-12: ~40-50%; 13-14: ~50-60%; >14: >80% mortality; delta-SOFA (24h change) is highly predictive: increasing SOFA indicates failure to respond to therapy.

How does cardiovascular SOFA account for vasopressors?

CV SOFA: 0=MAP≥70; 1=MAP 5 or epinephrine/norepinephrine≤0.1; 4=dopamine>15 or epinephrine/norepinephrine>0.1 mcg/kg/min.

Should SOFA use worst or first 24h values?

Traditional SOFA uses worst values in 24h; initial SOFA at admission and delta-SOFA (change over 24-48h) provide additional prognostic information; improving SOFA at 24h is associated with significantly better outcomes.

SOFA Score (Sequential Organ Failure Assessment)

Calculates the SOFA score across six organ systems (respiratory, coagulation, hepatic, cardiovascular, CNS, renal) to assess organ failure severity and predict mortality in ICU and sepsis patients.

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qSOFA Score