What is the target CPP in severe TBI?

Brain Trauma Foundation guidelines: target CPP 60-70 mmHg in severe TBI; below 60 associated with cerebral ischemia; above 70-80 associated with ARDS risk from aggressive fluid/vasopressor use; individualized based on autoregulation status.

At what ICP level should treatment be initiated?

ICP >20-22 mmHg for >5 minutes triggers treatment; Tier 1: positioning (HOB 30°), sedation/analgesia, normothermia, normocapnia; Tier 2: osmotherapy, CSF drainage; Tier 3: hypothermia, decompressive craniectomy, barbiturate coma.

What mannitol dose is used for ICP reduction?

Mannitol 0.25-1.5 g/kg IV (typically 1 g/kg for acute herniation); should maintain serum osmolality 315-320 or serum Na >160; hypertonic saline (3% or 23.4%) is an alternative.

What PCO2 target is used in severe TBI management?

Normocarbia PCO2 35-40 mmHg is the target; prophylactic hyperventilation (PCO2 <35) is NOT recommended; brief hyperventilation (PCO2 30-35 for <30 min) can be used for acute herniation as bridge to definitive treatment.

What is the Lund concept of ICP management?

Lund protocol prioritizes reducing cerebral blood volume via beta-blockers (metoprolol), alpha-agonists (clonidine), and vasopressors to maintain CPP 50-60 (lower target); contrasts with BTF high-CPP approach; used selectively in severely injured brains.

Intracranial Pressure Management and CPP Calculator

Calculates cerebral perfusion pressure (MAP - ICP), ICP tier treatment algorithm triggers, and osmotherapy dosing (mannitol, hypertonic saline) for elevated ICP management in TBI and neurocritical care.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the patient or scenario you are assessing. Calculates cerebral perfusion pressure (MAP - ICP), ICP tier treatment algorithm triggers, and osmotherapy dosing (mannitol, hypertonic saline) for elevated ICP management in TBI and neurocritical care. Use the icp cpp calculator result to inform your clinical assessment.

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