How is HOMA-IR calculated?

HOMA-IR = (Fasting insulin in mU/L x Fasting glucose in mmol/L) / 22.5. If glucose is in mg/dL, convert first: mmol/L = mg/dL divided by 18. Both values must be from a fasting state (8-12 hours).

What HOMA-IR value indicates insulin resistance?

Normal HOMA-IR is below 2.0. Values 2.0-2.9 suggest mild insulin resistance. HOMA-IR 3.0 or above indicates significant insulin resistance. However, cutoffs vary by ethnicity and laboratory assay.

What are the limitations of HOMA-IR?

HOMA-IR assumes a steady-state model and is less reliable in type 1 diabetes, advanced type 2 diabetes with beta cell failure, hepatic disease, and kidney disease. The hyperinsulinemic-euglycemic clamp remains the gold standard for insulin resistance measurement.

HOMA-IR Insulin Resistance Index

Calculate insulin resistance using HOMA-IR = (fasting insulin mU/L x fasting glucose mmol/L) / 22.5. Normal <2.0; insulin resistance 2.0-2.9; significant resistance 3.0+.

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Frequently Asked Questions

How is HOMA-IR calculated?

What HOMA-IR value indicates insulin resistance?

What are the limitations of HOMA-IR?