How is rivaroxaban adjusted for renal function in AF?

AF dose: CrCl ≥50 mL/min: 20 mg once daily with evening meal. CrCl 15–49 mL/min: 15 mg once daily with evening meal. CrCl <15 mL/min: avoid. VTE treatment: 15 mg BID × 21 days then 20 mg once daily; avoid if CrCl <30 mL/min. Drug interactions (strong CYP3A4/P-gp inhibitors) require avoidance regardless of renal function.

Why must rivaroxaban be taken with a meal?

Rivaroxaban 20 mg and 15 mg tablets require a meal (ideally evening meal) for adequate absorption—30% reduction in bioavailability if taken fasted. This is in contrast to apixaban and dabigatran which can be taken without food. Patient counseling on this point is clinically important for maintaining anticoagulant efficacy.

Rivaroxaban Renal Dose Adjustment Calculator

Determine appropriate rivaroxaban dosing for AF and VTE indications based on creatinine clearance, body weight, and indication-specific thresholds for dose reduction or avoidance.

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Frequently Asked Questions

How is rivaroxaban adjusted for renal function in AF?

Why must rivaroxaban be taken with a meal?