At what Breslow depth is SLNB recommended?

SLNB is standard for Breslow >=1.0mm. For Breslow 0.8-1.0mm with ulceration or Breslow <0.8mm with high-risk features (ulceration + high mitotic rate), SLNB discussion is recommended per NCCN guidelines.

Does SLNB improve survival in melanoma?

MSLT-I trial: SLNB improved regional disease-free survival and disease-specific survival in intermediate-thickness melanoma (1-4mm) when nodal disease found at SLNB rather than waiting for clinical recurrence.

What is the false-negative rate for SLNB in melanoma?

SLNB false-negative rate for melanoma is 4-16% depending on tumor location, number of sentinel nodes retrieved, and technique. Truncal melanoma has higher false-negative rates than head/neck or extremity.

SLN Sentinel Lymph Node Probability

Estimate sentinel lymph node positivity probability in melanoma. Breslow >0.8mm with ulceration or >1.0mm any melanoma has >5% SLNB positive rate warranting biopsy per NCCN/MSLT-I.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the scenario you are assessing. Estimate sentinel lymph node positivity probability in melanoma. Breslow >0.8mm with ulceration or >1.0mm any melanoma has >5% SLNB positive rate warranting biopsy per NCCN/MSLT-I. Use the slnb probability result to inform your calculation.

Related Calculators

Breslow Depth Melanoma

Hyper-niche Medical

AJCC 8th Melanoma TNM