How many TPE cycles are required for different neurological indications?

AIDP/GBS: 5 exchanges (200 to 250 mL/kg total) over 7 to 14 days = equivalent to IVIG 2 g/kg (do not combine). MG crisis: 5 to 7 exchanges, rapid response within 1 to 2 weeks. CIDP (acute): 5 exchanges, often repeated courses needed. NMOSD acute attack: 5 to 7 exchanges, start early if steroid-refractory. Acute CNS demyelination: evidence weakest for MS relapse (only confirmed refractory cases).

What are the complications of therapeutic plasma exchange?

Complications: citrate toxicity (hypocalcemia - tingling, tetany, arrhythmia; prevent with calcium supplements), allergic reactions to FFP (urticaria 5 to 15%, anaphylaxis <1%), hypotension from albumin replacement (lower oncotic pressure), central line complications (access-related), coagulopathy after multiple FFP sessions, hypogammaglobulinemia with albumin replacement in repeated sessions.

Therapeutic Plasma Exchange Cycles Calculator

Calculate total plasma exchange cycles needed by indication: TTP (daily until remission), MG crisis (5 exchanges), GBS (4 to 6 exchanges), FSGS recurrence (intensive), anti-GBM (14 sessions).

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Frequently Asked Questions

How many TPE cycles are required for different neurological indications?

What are the complications of therapeutic plasma exchange?