How is norepinephrine infusion rate calculated from dose?

Rate (mL/h) = [Dose (μg/kg/min) × Weight (kg) × 60] / Concentration (μg/mL); example: 0.1 μg/kg/min × 70 kg × 60 / 64 μg/mL (16 mg in 250 mL) = 6.6 mL/h.

What is the dose range for dobutamine in cardiogenic shock?

Dobutamine for cardiac output support: 2-20 μg/kg/min; inotropic effect at 2-5 (predominantly β1), vasodilation at 5-10 (additional β2), mild chronotropy throughout; tachycardia and arrhythmia are dose-limiting side effects.

What milrinone loading dose and maintenance are used?

Milrinone loading dose 25-75 μg/kg over 10 minutes (often omitted to avoid hypotension); maintenance 0.125-0.75 μg/kg/min; renally cleared - reduce dose by 50% when CrCl <30 mL/min.

When is dopamine still used despite norepinephrine preference?

Dopamine (3-10 μg/kg/min) may be used in bradycardic shock where tachycardia is desired; dopamine causes more arrhythmias than NE in septic shock; SOAP II trial showed higher 28-day mortality with dopamine in septic shock.

What vasopressor is used for right ventricular failure in sepsis?

Norepinephrine increases systemic vascular resistance without significantly increasing PVR, improving coronary perfusion pressure for the RV; vasopressin may be beneficial in pulmonary hypertension-related RV failure (does not increase PVR).

ICU Vasopressor and Inotrope Infusion Dosing Calculator

Calculates infusion rates for norepinephrine, epinephrine, dopamine, dobutamine, milrinone, and phenylephrine based on patient weight, desired dose, and drug concentration, with conversion between dose units.

Weight

Height

Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Each component has a specific meaning:

Patient weight — The patient weight recorded for the patient or scenario being assessed.
Desired dose — The desired dose recorded for the patient or scenario being assessed.
Drug concentration — The drug concentration recorded for the patient or scenario being assessed.

Note: Interpret the vasopressor dosing icu result against the clinical thresholds and context described above.

How to Use

Enter the patient weight, desired dose, drug concentration for the patient or scenario you are assessing. Calculates infusion rates for norepinephrine, epinephrine, dopamine, dobutamine, milrinone, and phenylephrine based on patient weight, desired dose, and drug concentration, with conversion between dose units. Use the vasopressor dosing icu result to inform your clinical assessment.

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